Thank you so much for providing such a clear, comprehensive explanation of what is a nuanced, grossly misunderstood subject of health. I always felt suspicious of the ubiquity of antioxidant propaganda! Now I feel like I finally understand it! Bless you, Andreas. Please keep up the good fight of truth and health for humanity, educating the world on the veritable panacea that is Chlorine Dioxide! Truth prevails eventually, and so many of us have you to thank personally for our health and wellbeing 🙏🏼
This article beautifully clarifies how oxidation and free radicals have been oversimplified and misunderstood. I believe we should take this understanding even further: oxidation is not a defect to be corrected, but a fundamental process of life itself—like breathing or metabolism.
Instead of seeing free radicals as enemies, we should recognize them as inevitable companions in the dynamic flow of life. The real “antioxidant” is the body’s ability to regenerate, repair, and maintain its structure despite continuous entropy. The balance is not in eliminating oxidation, but in strengthening the body’s adaptive and self-renewing capacities.
Thank you for opening the door to a more nuanced view. This is the beginning of a deeper paradigm shift.
Excellent article. Affirms the use of high doses of vitamin C is a neutralizer and antidote to CDS. It is impairative if desired to take vitamin C atleast 2 hours before or after using CDS.
This is really important and thank you Dr Kalcker…
The main antioxidant is God given Melatonin.. gifted from the sun.. but people think NAC is really the main one.. it is not.. also helps the cancer cell avoid cell death.. yes glutathione is a master oxidant that assists the cancer cell to survive by reducing those telltale markers the immune system uses to recognise a poorly performing cell.. I.e. 34 atp to 2 atp...
It should be noted that just because something is an antioxidant, it does not mean it cannot be used to fight cancer.
Example: Curcumin derivatives have antioxidant, anti-diabetic, anti-cancer, anti-allergic, anticoagulant, anti-fungal, and anti-infertility properties.
There are numerous studies highlighting the anticancer effects of curcumin, which come from the fact that curcumin regulates cell signaling pathways such as STAT3, NF-kB, activated Egr-1, AP-1, P53 [163], Wnt/β-catenin, PI3K/Akt, JAK/STAT, and MAPK [164].
I did not say not to use antioxidants per se.. I tried to point out that glutathione gets hijacked by cancer cells to help avoid programmed cell death.. cells get marked for destruction when the ROS rises too high..NAC helps to make the tri-peptide glutathione..which is fine when you don’t have cancer.. but if you are trying to stop every pathway to help a cancer cell survive ..then consider lowering you use of NAC…until after you had the chemo.
I would like to thank you for everything that you have contributed to so many people, like myself, that use your book, your notes and your knowledge to treat so many others of their ‘incurable’ diseases. We may be quiet (because we have come under the scrutiny of the authorities) but we read your articles, and learn so much that our knowledge becomes invaluable to those whose life is imperilled but seek alternative help from non-medical professionals. Your tireless work in this field is invaluable and the healing that I have witnessed from utilising your work is simply incredible.
Hundreds of my clients have seen their lives changed and thank me for it when all I have done is pass on your knowledge. You have touched the lives of millions, yet we have to fight every day to continue to use what you have taught us. We desperately need to see a change in attitude from the top but I fear that the possibility of CDS becoming legitimised is almost nil because the threat to those with a strong interest in keeping the status quo means they will fight to the death to continue the ban. Keep up the good work - you have a following far larger than you can imagine.
Thank you for sharing your wisdom, Dr. Kalcker. I am wondering what the impact of doing high-dose vitamin C IVs while also taking ClO2 for cancer might be? Positive? Negative? A wash?
High-dose vitamin C (ascorbate) can act as a pro-oxidant in the presence of catalytic transition metals (Fe³⁺/Cu²⁺). Pharmacologic millimolar ascorbate reduces Fe³⁺ to Fe²⁺, fueling the Fenton reaction: Fe²⁺ + H₂O₂ → Fe³⁺ + OH⁻ + •OH. Simultaneously, ascorbate autoxidation generates H₂O₂ extracellularly, especially in plasma and tumor interstitium where catalase is lower. The resulting H₂O₂ can diffuse into cells and, in metal-rich locales, yield hydroxyl radicals (•OH). These radicals have extremely high reduction potential and react at diffusion-limited rates with lipids, proteins, and DNA, causing oxidative damage when antioxidant defenses (catalase, GPx, peroxiredoxins, GSH) are overwhelmed. Thus, under metal-catalyzed conditions, high-dose vitamin C can shift from antioxidant to pro-oxidant, increasing oxidative redox stress that may become cytotoxic, particularly to cells with compromised peroxide-scavenging capacity.
I just want to make sure that I understand the takeaway from this. Are you saying that high-dose vitamin C infusions may be counter-productive to healing cancer? Are lower dose oral concentrations of vitamin C a better choice? And is it efficacious to take chlorine dioxide when also taking vitamin C orally (3,000mg daily)? Thank you in advance.
This post on the dual redox behavior of CDS is highly instructive. Of particular interest to me is the realization that my daily regimen including Vitamin C needs to be altered. In fact the vitamin C supplement I have been taking is not only unnecessary but also potentially harmful. I now wonder what other supplements I take may also be counterproductive and potentially harmful. Can you provide a list of other supplements that may need to be adjusted. For example I also take Zinc, Iron, Potassium, Vitamine D3, Vitamin k2, Vitamin E, Beta-Carotene, MCT Oil 8, and baby aspirin?
Everything is toxic, depending on the dose, time, and form of intake. Now I would like to add one more: circumstances... There are moments when certain supplements are good, but there are also moments when they are detrimental. We have to understand that life as we know it changes constantly. Fear is a great salesman but a bad advisor :)
Thank you, Dr. Kalcker, for your explanation. I believe the focus should not be on whether ClO₂ can “choose” what to oxidize, but whether its interactions in the body follow a predictable and verifiable feedback path.
The human body already has its own complex redox balancing systems. Any external intervention, to be truly useful, must act through clear, testable mechanisms—not by hoping for selective outcomes.
Perhaps the next step is to define precisely how ClO₂ influences these feedback loops, so its effects can be reliably predicted and applied.
So, how do we measure these values in human physiology? If we are seeking to tune, we must have a starting place and a means of assessment of interventions? We have several means of looking at pH, but that is only one factor in this balance. Sed rate comes to mind. CRP seems too far up the chain and not reflective of the environment we are manipulating.
To effectively assess the impact of interventions aimed at tuning the body's electrochemical balance, a comprehensive approach to measurement is required. While pH measurement provides valuable information regarding systemic acid-base status, it indeed represents only one aspect of the physiological milieu.
Additional markers that reflect cellular and extracellular environment include:
-Redox Potential (Eh): This parameter measures the oxidative-reductive state of bodily fluids and tissues, offering insight into cellular energy status and oxidative stress levels. Monitoring Eh can complement pH data by indicating the balance between oxidants and reductants, which directly affects cellular function.
-Electrolyte Balance: Levels of key ions such as sodium, potassium, calcium, magnesium, and chloride influence membrane potentials and cellular excitability. Regular assessment helps understand shifts in charge distribution that are fundamental to electromolecular medicine.
-Inflammatory Markers: While CRP is a downstream marker of inflammation, other markers like interleukin levels or fibrinogen might provide more immediate feedback on tissue environment changes without being too distal.
-Erythrocyte Sedimentation Rate (ESR): As you noted, ESR can reflect inflammatory activity but is influenced by multiple factors and may lack specificity for immediate environmental changes.
-Cellular Bioelectrical Properties: Emerging technologies such as bioimpedance analysis or direct measurement of membrane potentials can provide real-time data on cellular charge status and tissue hydration.
-Mitochondrial Function Tests: Since energy metabolism is closely tied to cellular charge dynamics, assessing mitochondrial activity via oxygen consumption rates or ATP production assays can be informative.
In practice, a panel combining pH, redox potential, electrolyte profiles, and specific biomarkers tailored to the clinical context offers the most robust framework for monitoring intervention effects. Continuous development of sensitive electrophysiological measurement tools will enhance our capacity to fine-tune therapeutic strategies in electromolecular medicine.
For detailed protocols and further guidance on integrating these assessments within therapeutic frameworks such as those involving Chlorine Dioxide Solution (CDS), I recommend consulting the resources available at andreaskalcker.com and dioxipedia.com.
Good article on testing. I compare this type of testing to standard medicine blood panels. As the average person becomes more knowledgeable by reading these articles it will be impairative for a person to pursue these alternative electro biomarkers. This is the future.
May I give a remark on the use of theterm lipid peroxidation in your piece. This is certainly not the normal beta-oxidation of fatty acids in the cell but refers to the oxidation of the double bonds in fatty acids leading to detrimental products
Interesting that all radicals are not bad...and antioxidants are not always beneficial.
Thank you for clarifying, much appreciated
Thank you so much for providing such a clear, comprehensive explanation of what is a nuanced, grossly misunderstood subject of health. I always felt suspicious of the ubiquity of antioxidant propaganda! Now I feel like I finally understand it! Bless you, Andreas. Please keep up the good fight of truth and health for humanity, educating the world on the veritable panacea that is Chlorine Dioxide! Truth prevails eventually, and so many of us have you to thank personally for our health and wellbeing 🙏🏼
This article beautifully clarifies how oxidation and free radicals have been oversimplified and misunderstood. I believe we should take this understanding even further: oxidation is not a defect to be corrected, but a fundamental process of life itself—like breathing or metabolism.
Instead of seeing free radicals as enemies, we should recognize them as inevitable companions in the dynamic flow of life. The real “antioxidant” is the body’s ability to regenerate, repair, and maintain its structure despite continuous entropy. The balance is not in eliminating oxidation, but in strengthening the body’s adaptive and self-renewing capacities.
Thank you for opening the door to a more nuanced view. This is the beginning of a deeper paradigm shift.
Excellent article. Affirms the use of high doses of vitamin C is a neutralizer and antidote to CDS. It is impairative if desired to take vitamin C atleast 2 hours before or after using CDS.
This is really important and thank you Dr Kalcker…
The main antioxidant is God given Melatonin.. gifted from the sun.. but people think NAC is really the main one.. it is not.. also helps the cancer cell avoid cell death.. yes glutathione is a master oxidant that assists the cancer cell to survive by reducing those telltale markers the immune system uses to recognise a poorly performing cell.. I.e. 34 atp to 2 atp...
Glutathione is an antioxidant, not an oxidant.
My bad.. I did mean antioxidant..I did know that as I have used NAC for the last 5 years as an antioxidant.
My problem is using a phone that likes to pop on predictive text.. and put words in place of the words you really meant.
It should be noted that just because something is an antioxidant, it does not mean it cannot be used to fight cancer.
Example: Curcumin derivatives have antioxidant, anti-diabetic, anti-cancer, anti-allergic, anticoagulant, anti-fungal, and anti-infertility properties.
There are numerous studies highlighting the anticancer effects of curcumin, which come from the fact that curcumin regulates cell signaling pathways such as STAT3, NF-kB, activated Egr-1, AP-1, P53 [163], Wnt/β-catenin, PI3K/Akt, JAK/STAT, and MAPK [164].
https://pmc.ncbi.nlm.nih.gov/articles/PMC10219365/
The redox environment is just one aspect. Of course separate from CDS treatment as appropriate.
I did not say not to use antioxidants per se.. I tried to point out that glutathione gets hijacked by cancer cells to help avoid programmed cell death.. cells get marked for destruction when the ROS rises too high..NAC helps to make the tri-peptide glutathione..which is fine when you don’t have cancer.. but if you are trying to stop every pathway to help a cancer cell survive ..then consider lowering you use of NAC…until after you had the chemo.
I would like to thank you for everything that you have contributed to so many people, like myself, that use your book, your notes and your knowledge to treat so many others of their ‘incurable’ diseases. We may be quiet (because we have come under the scrutiny of the authorities) but we read your articles, and learn so much that our knowledge becomes invaluable to those whose life is imperilled but seek alternative help from non-medical professionals. Your tireless work in this field is invaluable and the healing that I have witnessed from utilising your work is simply incredible.
Hundreds of my clients have seen their lives changed and thank me for it when all I have done is pass on your knowledge. You have touched the lives of millions, yet we have to fight every day to continue to use what you have taught us. We desperately need to see a change in attitude from the top but I fear that the possibility of CDS becoming legitimised is almost nil because the threat to those with a strong interest in keeping the status quo means they will fight to the death to continue the ban. Keep up the good work - you have a following far larger than you can imagine.
Hi Dr. Kalcker,
This material might interest you: https://open.substack.com/pub/clo2xuewuliu/p/06-rebuttal-to-wireds-smear-campaign?r=48chtc&utm_campaign=post&utm_medium=web&showWelcomeOnShare=false
You are a gift to truth, scientific integrity, skilled teaching and above all, to people who want to learn and help our fellow man. Deepest thanks.
Merci, voici des arguments de plus pour expliquer les anti-oxydants.
Thank you for sharing your wisdom, Dr. Kalcker. I am wondering what the impact of doing high-dose vitamin C IVs while also taking ClO2 for cancer might be? Positive? Negative? A wash?
It just does not make sense...
Thank you warmly for your kind reply, Dr. Kalcker. What would be the best way to get more insight into your response?
sure :
High-dose vitamin C (ascorbate) can act as a pro-oxidant in the presence of catalytic transition metals (Fe³⁺/Cu²⁺). Pharmacologic millimolar ascorbate reduces Fe³⁺ to Fe²⁺, fueling the Fenton reaction: Fe²⁺ + H₂O₂ → Fe³⁺ + OH⁻ + •OH. Simultaneously, ascorbate autoxidation generates H₂O₂ extracellularly, especially in plasma and tumor interstitium where catalase is lower. The resulting H₂O₂ can diffuse into cells and, in metal-rich locales, yield hydroxyl radicals (•OH). These radicals have extremely high reduction potential and react at diffusion-limited rates with lipids, proteins, and DNA, causing oxidative damage when antioxidant defenses (catalase, GPx, peroxiredoxins, GSH) are overwhelmed. Thus, under metal-catalyzed conditions, high-dose vitamin C can shift from antioxidant to pro-oxidant, increasing oxidative redox stress that may become cytotoxic, particularly to cells with compromised peroxide-scavenging capacity.
Dr.h.c. Andreas Ludwig Kalcker
I just want to make sure that I understand the takeaway from this. Are you saying that high-dose vitamin C infusions may be counter-productive to healing cancer? Are lower dose oral concentrations of vitamin C a better choice? And is it efficacious to take chlorine dioxide when also taking vitamin C orally (3,000mg daily)? Thank you in advance.
This post on the dual redox behavior of CDS is highly instructive. Of particular interest to me is the realization that my daily regimen including Vitamin C needs to be altered. In fact the vitamin C supplement I have been taking is not only unnecessary but also potentially harmful. I now wonder what other supplements I take may also be counterproductive and potentially harmful. Can you provide a list of other supplements that may need to be adjusted. For example I also take Zinc, Iron, Potassium, Vitamine D3, Vitamin k2, Vitamin E, Beta-Carotene, MCT Oil 8, and baby aspirin?
Everything is toxic, depending on the dose, time, and form of intake. Now I would like to add one more: circumstances... There are moments when certain supplements are good, but there are also moments when they are detrimental. We have to understand that life as we know it changes constantly. Fear is a great salesman but a bad advisor :)
Thank you, Dr. Kalcker, for your explanation. I believe the focus should not be on whether ClO₂ can “choose” what to oxidize, but whether its interactions in the body follow a predictable and verifiable feedback path.
The human body already has its own complex redox balancing systems. Any external intervention, to be truly useful, must act through clear, testable mechanisms—not by hoping for selective outcomes.
Perhaps the next step is to define precisely how ClO₂ influences these feedback loops, so its effects can be reliably predicted and applied.
So, how do we measure these values in human physiology? If we are seeking to tune, we must have a starting place and a means of assessment of interventions? We have several means of looking at pH, but that is only one factor in this balance. Sed rate comes to mind. CRP seems too far up the chain and not reflective of the environment we are manipulating.
To effectively assess the impact of interventions aimed at tuning the body's electrochemical balance, a comprehensive approach to measurement is required. While pH measurement provides valuable information regarding systemic acid-base status, it indeed represents only one aspect of the physiological milieu.
Additional markers that reflect cellular and extracellular environment include:
-Redox Potential (Eh): This parameter measures the oxidative-reductive state of bodily fluids and tissues, offering insight into cellular energy status and oxidative stress levels. Monitoring Eh can complement pH data by indicating the balance between oxidants and reductants, which directly affects cellular function.
-Electrolyte Balance: Levels of key ions such as sodium, potassium, calcium, magnesium, and chloride influence membrane potentials and cellular excitability. Regular assessment helps understand shifts in charge distribution that are fundamental to electromolecular medicine.
-Inflammatory Markers: While CRP is a downstream marker of inflammation, other markers like interleukin levels or fibrinogen might provide more immediate feedback on tissue environment changes without being too distal.
-Erythrocyte Sedimentation Rate (ESR): As you noted, ESR can reflect inflammatory activity but is influenced by multiple factors and may lack specificity for immediate environmental changes.
-Cellular Bioelectrical Properties: Emerging technologies such as bioimpedance analysis or direct measurement of membrane potentials can provide real-time data on cellular charge status and tissue hydration.
-Mitochondrial Function Tests: Since energy metabolism is closely tied to cellular charge dynamics, assessing mitochondrial activity via oxygen consumption rates or ATP production assays can be informative.
In practice, a panel combining pH, redox potential, electrolyte profiles, and specific biomarkers tailored to the clinical context offers the most robust framework for monitoring intervention effects. Continuous development of sensitive electrophysiological measurement tools will enhance our capacity to fine-tune therapeutic strategies in electromolecular medicine.
For detailed protocols and further guidance on integrating these assessments within therapeutic frameworks such as those involving Chlorine Dioxide Solution (CDS), I recommend consulting the resources available at andreaskalcker.com and dioxipedia.com.
Good article on testing. I compare this type of testing to standard medicine blood panels. As the average person becomes more knowledgeable by reading these articles it will be impairative for a person to pursue these alternative electro biomarkers. This is the future.
Thank you!
May I give a remark on the use of theterm lipid peroxidation in your piece. This is certainly not the normal beta-oxidation of fatty acids in the cell but refers to the oxidation of the double bonds in fatty acids leading to detrimental products
Thank you. Sorry, English is not my first language. Much appreciated.
Lipid peroxidation is ferroptisis which is the death knell to a cancer cell.
Another interesting aspect that needs more research! I like it.
Maybe it's worth a try... https://i.warosu.org/data/sci/img/0159/84/1705650137109269.pdf